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Application of a Chimeric Synthetic Peptide in the Development of a Serologic Method for the Diagnosis of Hepatitis G Virus Infection

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Abstract:

New putative antigenic peptides corresponding to the N- and C-terminal of the E2 envelope protein of GBVC/ HGV were synthesized using solid-phase chemistry. The antigens were obtained in linear and chimeric forms with the main aim of improving the sensitivity of the enzyme immunoassays. Furthermore, CD and FTIR have been used in conjunction to characterize their conformational changes showing that the chimeric peptide presents a more ordered secondary structure than its parent peptides.





Keywords: ELISA; Fourier transform infrared spectroscopy; Hepatitis G virus / GB virus C; chimeric peptides; circular dichroism; solid-phase peptide synthesis

Document Type: Research Article

DOI: https://doi.org/10.2174/092986607782110239

Publication date: 2007-09-01

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  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.
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