Pigment Epithelium-Derived Factor (PEDF) Prevents Advanced Glycation End Products (AGEs)-Elicited Endothelial Nitric Oxide Synthase (eNOS) Reduction Through Its Anti-Oxidative Properties
Authors: Sho-ichi Yamagishi; Seiji Ueda; Takanori Matsui; Kazuo Nakamura; Tsutomu Imaizumi; Masayoshi Takeuchi; Seiya Okuda
Source: Protein and Peptide Letters, Volume 14, Number 8, August 2007 , pp. 832-835(4)
Publisher: Bentham Science Publishers
Abstract:PEDF is an effective inhibitor of angiogenesis in the eye with neuronal differentiating activity. Here, we show that PEDF prevents the AGEs-elicited eNOS reduction through its anti-oxidative properties. Our present study suggests that PEDF may also play a protective role against atherosclerosis.
Document Type: Research Article
Publication date: 2007-08-01
- Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.