Pigment Epithelium-Derived Factor (PEDF) Inhibits Angiotensin IIInduced Smooth Muscle Cell Proliferation Through Its Anti-Oxidative Properties

Authors: Sho-ichi Yamagishi; Takanori Matsui; Kazuo Nakamura; Tsutomu Imaizumi

Source: Protein and Peptide Letters, Volume 14, Number 6, June 2007 , pp. 615-617(3)

Publisher: Bentham Science Publishers

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Pigment epithelium-derived factor (PEDF) is a potent inhibitor of angiogenesis, suggesting that loss of this factor may be involved in angiogenic eye disease. Here, we show that PEDF inhibits angiotensin II-induced smooth muscle cell proliferation through its anti-oxidative properties. Our present study suggests that PEDF may play a protective role against atherosclerosis.

Keywords: Angiotensin II; PEDF; atherosclerosis; oxidative stress

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986607780989976

Publication date: June 1, 2007

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  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.
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