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Interaction Profiling of T-Cell Epitopes with MHC-Class I Molecules

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Abstract:

A key step in rational vaccine development is to understand how antigens are recognized by their receptors. Several crystal structures of MHC/HLA molecules are now available. We report a structural bioinformatics study of peptide- HLA complexes to derive features that generate recognition specificity, useful for guiding the design process.





Keywords: Epitope prediction; HLA class-I; protein-peptide interaction; structural bioinformatics; vaccine design

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986607780989994

Publication date: June 1, 2007

More about this publication?
  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.
ben/ppl/2007/00000014/00000006/art00009
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