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Prediction of B Cell and T Cell Epitopes of DBLα Domain in Plasmodium falciparum Malaria Vaccine Candidate Var Gene

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Abstract:

P. falciparum encodes PfEMP-1 which is important in pathogenicity and virulence. We have analyzed the structure of the Duffy binding like (DBLα) domain of var genes and predicted the antigenic sites and T and B cell epitopes which present a highly variable picture with major implications in immune interactions and vaccine design.





Keywords: PfEMP1; antigenic sites; epitopes; malaria; var

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986607780989967

Publication date: June 1, 2007

More about this publication?
  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.
ben/ppl/2007/00000014/00000006/art00004
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