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Characterization of a Novel ADPase in Bothrops jararaca Snake Venom Involved in Nucleotide Hydrolysis

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Abstract:

Snake venoms hydrolyze several phosphorylated substrates. However, not is clearly understood which enzyme( s) is (are) involved in these process. Here, we propose the existence of an independent ADPase activity. In addition, we studied the reactions mechanism of nucleotide hydrolysis. This system resembles membrane ecto-nucleotidases and acts with a multi enzymatic complex transforming ATP in adenosine without the accumulation of intermediates.





Keywords: 5'-nucleotidase; ADPase; ATP-pyrophosphatase; ATPase; Bothrops jararaca; Phosphodiesterase

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986607780363998

Affiliations: Laboratorio de Quimica e Funcao de Proteinas e Peptideos, Universidade Estadual do Norte Fluminense,Avenida Alberto Lamego 2000, 28013-300 Campos dos Goytacazes,RJ, Brasil.

Publication date: April 1, 2007

More about this publication?
  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.
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