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Molecular Simulations of Rhodopsin Tetrameter

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Abstract:

Di/oligomerization of G-protein coupled receptors (GPCRs) is well established, however very little is known regarding the interaction details. Current paper presents results of molecular dynamics simulations of theoretical model of rhodopsin tetramer with transducine (Gt) in lipid bilayer. Ligand-protein and receptor-receptor interactions have been proposed.





Keywords: GPCRs; Oligomerization; molecular dynamics; rhodopsin; tetramer

Document Type: Research Article

DOI: https://doi.org/10.2174/092986607780363916

Affiliations: University of Gdansk, Faculty of Chemistry, ul. Sobieskiego 18, 80-952 Gdahsk, Poland.

Publication date: 2007-04-01

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  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.
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