Provider: Ingenta Connect
Database: Ingenta Connect
Content: application/x-research-info-systems
TY - ABST
AU - Agueci, Francesco
AU - Polticelli, Fabio
AU - Sinibaldi, Federica
AU - Cristina Piro, Maria
AU - Santucci, Roberto
AU - Fiorucci, Laura
TI - Probing the Effect of Mutations on Cytochrome c Stability
JO - Protein and Peptide Letters
PY - 2007-04-01T00:00:00///
VL - 14
IS - 4
SP - 335
EP - 339
KW - circular dichroism
KW - mutagenesis
KW - guanidinium chloride unfolding
KW - protein stability
KW - Cytochrome c
N2 - Although the tertiary structures of mitochondrial cytochromes c (cyts c) seem to be remarkably similar, there are variations in their amino acid sequences, stability and functional properties. GdnHCl-induced unfolding experiments on engineered yeast and horse cyt c were carried out with the aim to to clarify, at molecular level, some aspects concerning the stability of this class of proteins. The results obtained are discussed in the light of the three-dimensional structures of the two proteins.
UR - https://www.ingentaconnect.com/content/ben/ppl/2007/00000014/00000004/art00005
M3 - doi:10.2174/092986607780363989
UR - https://doi.org/10.2174/092986607780363989
ER -