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Biological Evaluation of Fluorinated p-Boronophenylalanine Derivatives as a Boron Carrier

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Abstract:

Boron neutron capture therapy (BNCT) and magnetic resonance imaging (MRI) are quite attractive techniques for treatment and diagnosis of cancer, respectively. In order to develop practical materials utilizing both for BNCT and MRI, fluorinated p-boronophenylalanines and their alcohol derivatives had already been designed and synthesized. In the present paper the cytotoxicity, the incorporated amount into cancer cells, and the tumor cell killing effects of these compounds were elucidated to evaluate their usefulness as a boron carrier.





Keywords: Boron neutron capture therapy (BNCT); boron carrier; fluorinated p-boronophenylalanine; tumor cell killing effect

Document Type: Research Article

DOI: https://doi.org/10.2174/092986607780090856

Affiliations: Faculty of Science and Technology,Kinki University, Higashi-osaka, Osaka 577-8502, Japan.

Publication date: 2007-03-01

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  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.
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