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Binding Sites on Laminin Receptors as Components for Antibiotics

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Abstract:

Bacteria use the receptor-adhesion-like interaction between laminin and the laminin receptor in the process of infection. We determined that bacteria do not interact with the receptor-binding site on laminin which could be expected for the bacterial laminin receptor. Rather, binding occurs via the laminin-binding site on the 67-kDa laminin receptor, which has a function similar to the one the bacterial laminin receptor possesses. This finding has implications for the effective use of antimicrobial peptides.





Keywords: Laminin; antimicrobial peptide; binding site; laminin receptor; minimum inhibitory concentration (MIC); prion

Document Type: Research Article

DOI: https://doi.org/10.2174/092986607779117290

Affiliations: Nagoya R&D Institute, Toagosei Co., Ltd., 1-1, Funami-cho, Minato-ku, Nagoya, 455-0027 Japan.

Publication date: 2007-01-01

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  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.
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