Neurotoxic Prion Protein (PrP) Fragment 106-126 Requires the N-terminal Half of the Hydrophobic Region of PrP in the PrP-Deficient Neuronal Cell Line
The cytotoxicity of aged PrP(106-126) was examined using an immortalized prion protein (PrP) gene-deficient neuronal cell line. The N-terminal half of the hydrophobic region (HR) but not the octapeptide repeat (OR) of PrP was required for aged PrP(106-126) neurotoxicity, suggesting that neurotoxic signals of aged PrP(106-126) are mediated by this region.
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Document Type: Research Article
Affiliations: Department of Molecular Immunology, School of Agricultural and Life Sciences, University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
Publication date: 01 January 2007
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