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Endomorphins Restored the Endothelium-Dependent Relaxation of the Rabbit Aorta Rings Exposed to High D-Glucose Condition Via NO-cGMP Pathway

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Abstract:

Rings of rabbit aorta that were both incubated in a high concentration of D-glucose and contracted submaximally by phenylephrine showed significantly decreased endothelium-dependent relaxations induced by acetylcholine. The cGMP production of aorta rings was also reduced. Treatment with endomorphins (1-1000 nmol/L) restored acetylcholineinduced relaxations of aorta rings incubated in high glucose concentrations and increased the cGMP synthesis. Moreover, this effect of endomorphins on endothelium was antagonized by naloxone, and the increase in the production of cGMP was also blocked.





Keywords: Endomorphin 1 (EM-1); aorta rings; cyclic guanosine monophosphate (cGMP); endomorphin 2 (EM-2); high glucose condition; naloxone (Nal)

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986606778777579

Affiliations: Department of Biochemistry and Molecular Biology, School of Life Science, Lanzhou University, 222 Tian Shui South Road, Lanzhou 730000, Gansu, P.R. China.

Publication date: October 1, 2006

More about this publication?
  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.
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