Endomorphins Restored the Endothelium-Dependent Relaxation of the Rabbit Aorta Rings Exposed to High D-Glucose Condition Via NO-cGMP Pathway
Abstract:Rings of rabbit aorta that were both incubated in a high concentration of D-glucose and contracted submaximally by phenylephrine showed significantly decreased endothelium-dependent relaxations induced by acetylcholine. The cGMP production of aorta rings was also reduced. Treatment with endomorphins (1-1000 nmol/L) restored acetylcholineinduced relaxations of aorta rings incubated in high glucose concentrations and increased the cGMP synthesis. Moreover, this effect of endomorphins on endothelium was antagonized by naloxone, and the increase in the production of cGMP was also blocked.
Document Type: Research Article
Affiliations: Department of Biochemistry and Molecular Biology, School of Life Science, Lanzhou University, 222 Tian Shui South Road, Lanzhou 730000, Gansu, P.R. China.
Publication date: October 1, 2006
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