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Antiviral Properties of Combination Peptides of HIV-1 Rev NLS and NES

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Nuclear translocation signal has been identified as a mediator of protein shuttling between nuclear and cytoplasm. Here we report that the combination of peptides from nuclear localization signal (NLS) and nuclear export signal (NES) of HIV-1 Rev have an antiviral activity against the Herpes virus of turkey and Marek's disease virus serotype 1.

Keywords: HIV-1 Rev; Herpes virus of turkey (HVT); Marek 's disease virus serotype 1 (MDV-1); Nuclear localization signal (NLS); antiviral peptide; nuclear export signal (NES)

Document Type: Research Article


Affiliations: Nagoya R&D Institute, Toagosei Co., Ltd., 1-1, Funami-cho, Minato-ku, Nagoya, Japan, 455-0027.

Publication date: October 1, 2006

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  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.

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