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Roles of Nitric Oxide Synthase inhibitor on Antinociceptive Effects of μ-Opioid Agonist in Mice

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In the present study, it was found that intraperitoneal (i.p.) pre-injection of NG-nitro-L-arginine methyl ester (LNAME) significantly influenced the endomorphin-1 (EM-1) and endomorphin-2 (EM-2) induced antinociception. These effects could be inhibited or reversed by L-Arg or naloxone. Our results suggest that the modulatory effect of NO system on the mu-receptor evoked analgesia is different between the two mu receptor subtypes.

Keywords: Analgesia; Endomorphin; L-arginine; Mice; NG-nitro-L-arginine methyl ester; Nitric oxide

Document Type: Research Article


Affiliations: Department of Bioengineering,Zhengzhou University, 100 Science Road, Zhengzhou, 450001, P. R.China.

Publication date: October 1, 2006

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  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.

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