Roles of Nitric Oxide Synthase inhibitor on Antinociceptive Effects of μ-Opioid Agonist in Mice
Abstract:In the present study, it was found that intraperitoneal (i.p.) pre-injection of NG-nitro-L-arginine methyl ester (LNAME) significantly influenced the endomorphin-1 (EM-1) and endomorphin-2 (EM-2) induced antinociception. These effects could be inhibited or reversed by L-Arg or naloxone. Our results suggest that the modulatory effect of NO system on the mu-receptor evoked analgesia is different between the two mu receptor subtypes.
Document Type: Research Article
Affiliations: Department of Bioengineering,Zhengzhou University, 100 Science Road, Zhengzhou, 450001, P. R.China.
Publication date: October 1, 2006
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