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Antimicrobial Properties of Nuclear Diffusion Inhibitory Signal of HIV-1 Rev

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Abstract:

Nuclear Diffusion Inhibitory Signal (NIS) has been identified in human immunodeficiency virus type 1 (HIV- 1) Rev as a nuclear signal peptide which modulates nucleocytoplasmic protein trafficking and intracellular stability of the HIV-1 Rev. In this study, it was discovered that antimicrobial properties are inherent in the NIS. This is a significant finding that the NIS, which does not exist solely for self defense, in fact possesses antimicrobial properties.





Keywords: HIV-1 Rev; Nuclear diffusion inhibitory signal (NIS); antimicrobial activity; antimicrobial peptide; minimum inhibitory concentration (MIC)

Document Type: Research Article

DOI: https://doi.org/10.2174/092986606777841217

Affiliations: Nagoya R&D Institute, Toagosei Co., Ltd., 1-1, Funami-cho, Minato-ku, Nagoya, Japan, 455-0027.

Publication date: 2006-08-01

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  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.
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