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Synthesis of Peptidyl Ureas Employing O-succinimidyl-(9H-fluoren-9- ylmethoxycarbonylamino)methylcarbamate Derivatives as Activated Monomers

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A convenient and efficient method for the synthesis of dipeptidyl ureas and urea acids employing Osuccinimidyl-( 9H-fluoren-9-ylmethoxycarbonyl amino)methylcarbamates has been described. All the compounds, obtained in good yields, have been fully characterized by mass and NMR spectra.

Keywords: Dipeptidyl Urea Acids; NMR; Schotten-Baumann conditions; dichloromethane (DCM); protease

Document Type: Research Article


Affiliations: Department of Studies in Chemistry, Central College Campus, Bangalore University, Dr. B. R. Ambedkar Veedhi, Bangalore 560 001, India.

Publication date: May 1, 2006

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  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.

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