Proteome Analysis of Resting Human Neutrophils
Abstract:Neutrophils constitute the first line of host defense against pathogens. In the present study 2-D gel electrophoresis- mass spectrometry technology was employed to analyze the human resting neutrophils proteome. One hundred and two conserved spots were subjected to peptide mass fingerprinting, yielding 22 identifications. Among the identified proteins, nine are related to the inflammatory process, two polypeptides are assigned to metabolic functions and five are classified as structural.
Document Type: Research Article
Affiliations: University of Brasilia, Departamento de Biologia Celular - UnB - ICC Sul, 70910-900 - Brasilia - DF - Brazil.
Publication date: 2006-05-01
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- Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.