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Home / Protein and Peptide Letters, Volume 13, Number 4

Comparative Study of Apoptosis Induced by H2O2 and NO: Limitation of Apoptosis Induced by NO Due to Slower Recovery of Activity of NOModified Caspase

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Both H2O2 and NO can act as apoptogens, triggering apoptosis in many cells. They are also well known inhibitors of caspases, essential enzymes in apoptosis. The differences between these two agents as apoptosis inducers and how caspases mediate apoptosis with these inhibitory agents is still unclear. Consistent with the previous reports, these two agents induced apoptosis accompanied by caspase activation with limitation of all apoptotic events for NO. It was found that NO-modified caspase-3 showed a slower recovery of its activity in the presence of the reducing agents compared to that of H2O2 modification. This is one possible cause of the limited apoptosis in the case of NO.





Keywords: H2O2; NO; apoptosis; caspase

Document Type: Research Article

Affiliations: Research Center for Proteineous Materials (RCPM) and Department of Bio-Materials Engineering, Chosun University, Gwangju 501-759, Korea and Department of Chemistry, Yonsei University, Wonju, Korea.

Publication date: 01 April 2006

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  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.
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