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Amyloid Under the Atomic Force Microscope

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Abstract:

The atomic force microscope (AFM) is a versatile instrument that can be used to image biological samples at nanometre resolution as well as to measure inter and intra-molecular forces in air and liquid environments. This review summarises the use of AFM applied to protein and peptide self-assembly systems involved in amyloid formation. The technical principles of the AFM are outlined and its advantages and disadvantages are highlighted and discussed in the context of the rapidly developing field of amyloid research.





Keywords: 3D topography; Tapping mode; amyloid fibrils; biomimetic environments; contact mode; functional surfaces; self-assembly; time-lapse microscopy

Document Type: Research Article

DOI: https://doi.org/10.2174/092986606775338498

Affiliations: Molecular and Nanoscale Physics Group, School of Physics and Astronomy, University of Leeds, EC Stoner Building, Woodhouse Lane, Leeds, LS2 9JT, UK.

Publication date: 2006-03-01

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  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.
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