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Quasielastic Light Scattering Study of Amyloid β-Protein Fibril Formation

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Abstract:

Quasielastic light scattering spectroscopy (QLS) is an optical method for the determination of diffusion coefficients of particles in solution. Here we discuss the principles of QLS and explain how the distribution of particle sizes can be reconstructed from the measured correlation function of scattered light. Non-invasive observation of the temporal evolution of particle sizes provides a powerful tool for studying protein assembly. We illustrate practical applications of QLS with examples from studies of fibril formation of the amyloid β-protein.





Keywords: Alzheimer's disease; aggregation; amyloid β-protein; elongation; fibril formation; nucleation; quasielastic light scattering; regularization

Document Type: Research Article

DOI: https://doi.org/10.2174/092986606775338515

Affiliations: Department of Physics, MIT, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

Publication date: 2006-03-01

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  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.
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