Influence of Human B-Casomorphin-7 on Specific Binding of 3H-Spiperone to the 5-HT2-Receptors of Rat Brain Frontal Cortex
Abstract:Using radio-receptor analysis, it has been demonstrated that human ε-casomorphin-7 (Tyr-Pro-Phe-Val- Glu-Pro-Ile) displaces 3H-spiperone from 5-HT2-receptors of rat brain frontal cortex. IC50 of human β-casomorphin-7 was 8 μM. These data suggest that one of the mechanisms of neurotropic action of β-casomorphin-7 is might be associated with its influence on the serotoninergic system.
Document Type: Research Article
Affiliations: National Research Center for Mental Health, Russian Academy of Medical Sciences, Moscow, Russia.
Publication date: February 1, 2006
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