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Synthesis, Characterization and Biological Activity of Chemically Modified Insulin Derivative with Alpha Lipoic Acid

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A novel chemically-modified insulin, ε-NB29-lipoyl insulin, was selectively prepared by the covalent linkage of α-lipoic acid (LA) to the ε-amino group of LysB29 of insulin without any protecting agent and analyzed by PAGE, HPLC, MALDI-TOF-MS. Monolipoyl- insulin maintained the glucose-lowering effect as well as native insulin and showed A longer duration of action than native insulin and an inhibitory effect towards trypsin degradation.

Keywords: Insulin; chemical modification; lipoyl-insulin; monolipoyl-insulin; α-lipoic acid

Document Type: Research Article


Affiliations: Department of Chemistry, Huazhong University of Science and Technology, Wuhan 430074, P.R. China.

Publication date: February 1, 2006

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  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.

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