Synthesis, Characterization and Biological Activity of Chemically Modified Insulin Derivative with Alpha Lipoic Acid

Authors: Huang, Tao¹; Huang, Kaixun¹

Source: Protein and Peptide Letters, Volume 13, Number 2, February 2006 , pp. 135-142(8)

Publisher: Bentham Science Publishers

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Abstract:

A novel chemically-modified insulin, ε-NB29-lipoyl insulin, was selectively prepared by the covalent linkage of α-lipoic acid (LA) to the ε-amino group of LysB29 of insulin without any protecting agent and analyzed by PAGE, HPLC, MALDI-TOF-MS. Monolipoyl- insulin maintained the glucose-lowering effect as well as native insulin and showed A longer duration of action than native insulin and an inhibitory effect towards trypsin degradation.

Keywords: Insulin; α-lipoic acid; chemical modification; lipoyl-insulin; monolipoyl-insulin

Document Type: Research article

DOI: 10.2174/092986606775101599

Affiliations: 1: Department of Chemistry, Huazhong University of Science and Technology, Wuhan 430074, P.R. China.

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