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The Cardioprotective Peptide, Urocortin, Activates Cardiac KATP Channels in Adult Rat.

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Urocortin (UCN), an endogenous cardioprotective peptide, has been reported to activate several ion channels but its effects on the cardiac KATP channels are unknown. In this paper, we showed that adult rat cardiac myocytes had small KATP currents that could be increased 20-fold by pinacidil. UCN also concentration-dependently activated the KATP current and this effect was influenced by ATP and PKA inhibitor peptide, Rp-cAMPS.





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Keywords: Cardiac myocytes; KATP channel; PKA; Pinacidil; Urocortin

Document Type: Research Article

Affiliations: Department of Pharmacology, Nanjing Medical University, Nanjing 210029, China.

Publication date: 2006-01-01

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  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.
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