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Expressed Protein Ligation to Obtain Selectively Modified Aldo/Keto Reductases

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Specific enzyme immobilization has moved into the focus for many applications in biochemical research fields. Expressed Protein Ligation (EPL) has been proven to be ideal to selectively label proteins at single positions. Applying this technique to enzymes of the aldo/keto reductase superfamily provides a new approach to generate native or modified redox enzymes for direct and indirect immobilization.

Keywords: akr a; aldo/keto reductase (akr); artificial redoxproteins; expressed protein ligation (epl); site specific covalent immobilization

Document Type: Review Article


Affiliations: Institute of Biochemistry, Faculty of Biosciences, Pharmacy and Psychology, University of Leipzig, Bruderstrabe 34, D-04103 Leipzig, Germany.

Publication date: 2005-11-01

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  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.
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