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Crystal Structure of Non-Fused Glutathione S-Transferase from Schistosoma 709 japonicum in Complex with Glutathione

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Abstract:

Schistosoma japonicum glutathione S-transferase (SjGST) is a common fusion tag in recombinant protein production, and its 3-dimensional structure has been studied in the context of drug design. We have determined the crystal structure of non-fused SjGST complexed with glutathione, and compare it to complexes between glutathione and SjGST fusion proteins.

Keywords: crystal structure; fusion protein; glutathione; gst; schistosoma japonicum

Document Type: Review Article

DOI: https://doi.org/10.2174/0929866054696154

Affiliations: EMBL-Hamburg/DESY, Notkestrasse 85, D-22603 Hamburg, Germany;

Publication date: 2005-10-01

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  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.
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