Predicted and Measured Disorder in Peripherin/rds, a Retinal Tetraspanin
Authors: Ritter, L. M.; Arakawa, T.; Goldberg, A. F.X.
Source: Protein and Peptide Letters, Volume 12, Number 7, October 2005 , pp. 677-686(10)
Publisher: Bentham Science Publishers
Abstract:Vertebrate photoreceptor outer segment (OS) morphogenesis requires peripherin/rds (P/rds). We have characterized this protein's C-terminus and present evidence that suggests it is intrinsically disordered. We propose that structural flexibility may underlie the multifunctionality proposed for this domain previously. The extremely short Ctermini present in other tetraspanin family members suggest that intrinsic disorder may also play a role for those proteins.
Document Type: Review article
Publication date: 2005-10-01
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