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Propensity of Amino Acids in Loop Regions Connecting Beta-Strands

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Abstract:

The fact that loops assume important roles in molecular functions and biological recognition is well known. In this study the Propensity and the Relative entropy of amino-acids in loop structures connecting beta-strands are calculated. Results showed that Asn is the most frequently occurring amino-acid in loop regions connecting beta-strands, followed by Gly, Asp, Ser, and Thr. Results presented here can serve for modeling loop structures connecting beta-strands in proteins.

Keywords: amino acid; loop; prediction; propensity; protein; relative entropy; secondary structure

Document Type: Review Article

DOI: https://doi.org/10.2174/0929866053765617

Affiliations: National Institute for Genetic Engineering and Biotechnology, Tehran 14155-6343, Iran.

Publication date: 2005-05-01

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  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.
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