Pharmacological Comparison of Two Different Insect Models Using the Scorpion α-Like Toxin BmK M1 from Buthus martensii Karsch
Abstract:In this study, the effect of the scorpion a-like toxin BmK M1 was investigated on isolated DUM neurons from Locusta migratoria and compared with the effect on para/tipE voltage-gated Na+ channels (VGSC), cloned from Drosophila melanogaster. The two insects display different pharmacological properties regarding α-like toxins. Moreover, with the aid of the α-like toxin BmK M1 and 5 of its mutants, the importance of aromatic residues for the interaction of the toxin with the VGSC in L. migratoria and D. melanogaster, is shown.
Document Type: Review Article
Affiliations: Laboratory of Toxicology, University of Leuven, E. Van Evenstraat 4, B-3000 Leuven, Belgium.
Publication date: 2005-05-01
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