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Information Theory in Prediction of Cleavage Sites of Signal Peptides

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Information theory is used to analyze the character of signal peptide quantitatively, especially residents. On the basis of the above analysis, a method named simplified information-matrix has been developed to predict the cleavage sites of signal peptides. A comparison between the results of weight-matrix and simplified information-matrix is presented.
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Keywords: cleavage sites; information entropy; information-matrix; signal peptide

Document Type: Review Article

Affiliations: 2002 Master Department of physics, School of Science, Tianjin University, Tianjin, 300072, P.R.China.

Publication date: 2005-05-01

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  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.
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