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[TIC4]Endomorphins, Analogues of Endomorphins, Have Significantly Enhanced Vasorelaxant Effects in Rat Aorta Rings

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Abstract:

[Tic4]EM1 and [Tic4]EM2, new endomorphins (EMs) analogues, caused relaxation of rat aorta rings precontracted with phenylphrine in a concentration-dependent manner and were 240- to 370-fold more potent than EMs. This effect was inhibited by endothelium removal or by incubation with NO synthase inhibitor L-NNA or opioid receptor antagonist naloxone. The results demonstrate that [Tic4]EMs have NO- and endothelium-dependent vasorelaxant effects which are mediated by the opioid receptor.

Keywords: endomorphins; opioid; rat aorta rings; tic; vasorelaxant response

Document Type: Review Article

DOI: http://dx.doi.org/10.2174/0929866053765743

Affiliations: Department of Biochemistry and Molecular Biology, School of Life Science, Lanzhou University, Lanzhou 730000, Peoples Republic of China.

Publication date: May 1, 2005

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  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.

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