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Efficient Method for the Synthesis of an Important Precursor of Constrained Peptides

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A practical method for the synthesis of an important precursor of constrained peptides involving only three steps from commercial inexpensive precursors is reported.

Keywords: constrained peptide; grubbs catalyst; ring closing metathesis; synthesis

Document Type: Review Article


Publication date: April 1, 2005

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  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.

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