The Hypothesis of the Catalytic Action of Nucleic Acid on the Conversion of Prion Protein
Abstract:The main hypothesis for prion diseases proposes that the cellular protein (PrPC) can be altered into a misfolded, β-sheet-rich isoform (PrPSc). We describe here that host nucleic acid may catalyze the conversion between PrPC and PrPSc isoforms, by reducing the protein mobility and by making the protein-protein interactions more likely. We summarize the findings, focusing in the biological relevance of the catalytic action of nucleic acid.
Document Type: Review Article
Affiliations: Departamento de Bioquimica Medica, Centro Nacional de Ressonancia Magnetica Nuclear de Macromoleculas, Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, RJ 21941-590, Brazil.
Publication date: April 1, 2005
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