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Protein Folding, Misfolding and Aggregation: Evolving Concepts and Conformational Diseases

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Abstract:

Proteins carry out many vital cellular functions determined by their precise 3-dimensional structures (the native conformations). Understanding how proteins fold has long been a major goal and can be of great therapeutic value. Failure to reach or maintain the correct folded structure can have serious consequences, as in the conformational diseases. The ultimate goal of folding studies is to predict structure from sequence, allowing the design of new functional proteins and prevention of aberrant disease-associated conformations.

Keywords: aggregation; amyloid; amyloidoses; misfolding; protein folding

Document Type: Review Article

DOI: https://doi.org/10.2174/0929866053587156

Affiliations: Centro de Biologia Molecular Estrutural, Laboratorio Nacional de Luz Sincrotron, PO Box 6192, Campinas SP 13084-971, Brazil.

Publication date: 2005-04-01

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  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.
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