Polypeptide Models to Understand Misfolding and Amyloidogenesis and Their Relevance in Protein Design and Therapeutics
Author: Zurdo, Jesus
Source: Protein and Peptide Letters, Volume 12, Number 2, February 2005 , pp. 171-187(17)
Publisher: Bentham Science Publishers
Abstract:The study of amyloid polypeptide models (polypeptides able to generate amyloid structures not necessarily connected with any pathology) provides an excellent tool to increase the understanding of the generic aspects of misfolding and aggregation as well as the details of the mechanism of polypeptide deposition in disease. This knowledge can be integrated and applied to different problems in therapy and biotechnology, and in particular to re-designing bioactive polypeptides (biopharmaceuticals) with improved properties.
Document Type: Review Article
Affiliations: Leverhulme Centre for Biological Complexity. Department of Chemistry, University of Cambridge. Lensfield Road, Cambridge CB2 1EW, UK.
Publication date: February 1, 2005
- Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.