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Immunocontinuum: Perspectives in Antimicrobial Peptide Mechanisms of Action and Resistance

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Antimicrobial peptides are present in organisms spanning virtually every kingdom, and employ sophisticated mechanisms to exert rapid microbicidal action consistent with their key roles in host defense. Offsetting these mechanisms, some microbial pathogens have evolved complex countermeasures to neutralize exposure to and subvert mechanisms of antimicrobial peptides. The following discussion highlights recent advances that offer greater understanding of the mechanisms of action and resistance of antimicrobial peptides.

Keywords: antimicrobial; mechanism; peptide; resistance

Document Type: Review Article


Affiliations: Division of Infectious Diseases, St. John's Cardiovascular Research Center, Research & Los Angeles Biomedical Research Center at Harbor-UCLA, Medical Center, 1124 West Carson Street, RB-2, Torrance, CA 90502.

Publication date: January 1, 2005

More about this publication?
  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.

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