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Antimicrobial Peptide Microbicides Targeting HIV

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Abstract:

Cationic antimicrobial peptides and proteins are among the earliest molecular effectors of the innate arm of immunity in humans and other vertebrates. This review, inspired by recent emphasis on the development of topical preventatives for sexually transmitted infections, describes antimicrobial peptides and proteins in the context of microbicide design and development. Particular emphasis is placed on the defensin family of peptides.

Keywords: antimicrobial; cathelicidin; defensin; hiv-1; human; minidefensin; peptide; std

Document Type: Review Article

DOI: http://dx.doi.org/10.2174/0929866053406101

Affiliations: Department of Molecular Biology and Microbiology, Biomolecular Science Center, University of Central Florida, Bldg 20, Room 136, 4000 Central Florida Blvd., Orlando FL 32816-2364.

Publication date: January 1, 2005

More about this publication?
  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.
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