Antimicrobial Peptides: Cooperative Approaches to Protection

Authors: Patrzykat, Aleksander; Douglas, Susan E.

Source: Protein and Peptide Letters, Volume 12, Number 1, January 2005 , pp. 19-25(7)

Publisher: Bentham Science Publishers

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Abstract:

Reports of cationic antimicrobial peptides (CAPs) have become standard fare in research literature. But with several hundred peptides described to date, the investigator who tries to navigate the proposed models of their activity is only treated to a generous serving of incongruencies. Rather than acting in isolation as antimicrobial molecules, CAPs also may synergize with other molecules of innate immunity and modulate both innate and adaptive immune systems, thus providing a link between the various mechanisms that result in host protection.

Keywords: antibiotic; biodiversity; cationic antimicrobial peptide; fish; genomics; microbicidal; synergy

Document Type: Review Article

DOI: http://dx.doi.org/10.2174/0929866053406057

Affiliations: Institute for Marine Biosciences, 1411 Oxford Street, Halifax, Nova Scotia, CANADA, B3H 3Z1.

Publication date: January 1, 2005

More about this publication?
  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.
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