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Synthesis of a Shark Repellent Peptide Toxin, Pardaxin (16-33) on a Highly Flexible Polymer Support: Clpser

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Abstract:

A high swelling resin, CLPSER has been developed and utilized for the solid phase synthesis of Pardaxin, which is an 18-residue peptide. The resin was characterized by gel phase 13C NMR, IR and SEM. The utility of the new polymer support in polypeptide synthesis was further established by the comparative synthesis of pardaxin with commercially available Merrifield resin. The MALDI TOF MS, amino acid analysis and the HPLC revealed the superior quality of CLPSER.

Keywords: clpser support; polymerization; solid phase peptide synthesis; swelling

Document Type: Review Article

DOI: https://doi.org/10.2174/0929866043406175

Affiliations: Rajiv Gandhi Centre for Biotechnology, Poojappura, Thiruvananthapuram, 695 014, Kerala, India.

Publication date: 2004-12-01

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  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.
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