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Versatile Synthesis of Boc Protected Hydrazinoacetic Acid and its Application to the Chemoselective Ligation of Tasp Molecules

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Abstract:

This paper describes a convenient synthesis of protected hydrazine derivatives, i.e. 1,2-bis-Bochydrazinoacetic acid, and its application for hydrazone ligation techniques in convergent template assembled synthetic protein (TASP) synthesis.

Keywords: amino acids; chemoselective ligation; electrophilic amino group; n-boc-3-(4-cyanophenyl)oxaziridine (bpco); synthesis; template assembled synthetic proteins (tasp)

Document Type: Review Article

DOI: https://doi.org/10.2174/0929866043406274

Affiliations: Institute of Chemical Sciences and Engineering (ISIC) Federal Institute of Technology Lausanne (EPFL), CH-1015 Lausanne, Switzerland.

Publication date: 2004-12-01

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  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.
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