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Correlation Between Hydrophobicity Sequence and Accessibility Sequence of Membrane Proteins

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In this paper, we used correlation analysis to quantify the correlations between the hydrophobicity sequence and accessibility sequence of 26 α-helix bundle membrane proteins and 119 transmembrane helices. Statistical significances of these correlations were also assessed. A slightly positive correlation was found in the α-helix bundle membrane proteins due to the contribution of extramembranous domains. No correlation was found in the transmembrane domains.
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Keywords: accessibility; correlation analysis; hydrophobicity; membrane protein

Document Type: Review Article

Affiliations: State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China.

Publication date: 01 December 2004

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