Dine (Damage-Induced Neuronal Endopeptidase)
A unique central nervous system (CNS)-specific metalloprotease, DINE / ECEL1 (damage induced neuronal endopeptidase / endothelin converting enzyme-like 1), has recently been added to the M13 / neprilysin (NEP) family. This enzyme was identified by two groups independently using different approaches. In this review, we introduce the characteristics of DINE / ECEL1 and focus on the mechanism underlying the transcriptional regulation of DINE in response to neuronal injury.
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Document Type: Review Article
Affiliations: Department of Anatomy and Neurobiology, Osaka City University, Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku Osaka 545-8585, Japan.
Publication date: 2004-10-01
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