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Dine (Damage-Induced Neuronal Endopeptidase)

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A unique central nervous system (CNS)-specific metalloprotease, DINE / ECEL1 (damage induced neuronal endopeptidase / endothelin converting enzyme-like 1), has recently been added to the M13 / neprilysin (NEP) family. This enzyme was identified by two groups independently using different approaches. In this review, we introduce the characteristics of DINE / ECEL1 and focus on the mechanism underlying the transcriptional regulation of DINE in response to neuronal injury.
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Keywords: dine; ecel1; leukemia inhibitory factor (lif); neprilysin; nerve injury; neuron; neuropeptides; survival

Document Type: Review Article

Affiliations: Department of Anatomy and Neurobiology, Osaka City University, Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku Osaka 545-8585, Japan.

Publication date: 2004-10-01

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  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.
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