If you are experiencing problems downloading PDF or HTML fulltext, our helpdesk recommend clearing your browser cache and trying again. If you need help in clearing your cache, please click here . Still need help? Email help@ingentaconnect.com

Secretase-Mediated Cell Surface Shedding of the Angiotensin-Converting Enzyme

$63.10 plus tax (Refund Policy)

Buy Article:

Abstract:

Angiotensin-converting enzyme (ACE) is an example of a membrane-bound protein, which is shed from the cell surface in a soluble form by a post-translational proteolytic cleavage event involving a secretase. The secretase cleavage site in somatic ACE has been mapped to Arg-1203 / Ser-1204, 24 residues proximal to the membrane-anchoring domain and the ADAM (‘a d isintegrin a nd m etalloprotease’) family of proteins may be involved in ACE shedding.

Keywords: ace; angiotensin; disintegrin; hypertension; metalloproteinase; proteolysis; secretase; shedding

Document Type: Review Article

DOI: http://dx.doi.org/10.2174/0929866043406544

Affiliations: Proteolysis Research Group, School of Biochemistry and Molecular Biology, University of Leeds, Leeds LS2 9JT, UK.

Publication date: October 1, 2004

More about this publication?
  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.
Related content

Tools

Favourites

Share Content

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more