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α-Synuclein Aggregation

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α-Synuclein is a major component of Lewy bodies in Parkinson's disease and is found associated with several other forms of dementia. As with other neurodegenerative diseases, the ability of α-synuclein to aggregate and form fibrillar deposits seems central to its pathology. We have defined a sequence within the NAC region of α-synuclein that is necessary for aggregation. Exploitation of chemically modified analogues of this peptide may produce inhibitors of aggregation.

Keywords: aggregation; amyloid; parkinsons disease; synuclein

Document Type: Review Article


Affiliations: University of Arkansas for Medical Sciences, Donald W. Reynolds Center on Aging, Little Rock, AR 72205, USA;

Publication date: 2004-06-01

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  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.
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