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Vatairea Macrocarpa Lectin Induces Paw Edema With Leukocyte Infiltration.

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A lectin from Vatairea macrocarpa (Vmac) seeds was investigated in a model of paw edema in rats and the possible involvement of leukocytes. Vmac (200 and 400μg / paw, s.c.) induced a significant time- and dose-dependent paw edema, with leukocyte infiltration, which was drastically reduced in leukopaenic animals. These data suggest a pro-inflammatory effect for this lectin that is dependent on the presence of leukocytes.

Keywords: Vatairea macrocarpa lectin; leukocyte infiltration; paw edema

Document Type: Review Article


Affiliations: Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Ceara, Cel Nunes de Melo 1127, CEP 60430-270 Fortaleza-CE Brasil.

Publication date: April 1, 2004

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  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.

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