Vatairea Macrocarpa Lectin Induces Paw Edema With Leukocyte Infiltration.
A lectin from Vatairea macrocarpa (Vmac) seeds was investigated in a model of paw edema in rats and the possible involvement of leukocytes. Vmac (200 and 400μg / paw, s.c.) induced a significant time- and dose-dependent paw edema, with leukocyte infiltration, which was drastically reduced in leukopaenic animals. These data suggest a pro-inflammatory effect for this lectin that is dependent on the presence of leukocytes.
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Document Type: Review Article
Affiliations: Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Ceara, Cel Nunes de Melo 1127, CEP 60430-270 Fortaleza-CE Brasil.
Publication date: 2004-04-01
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