Differential Desensitization of Somatostatin Receptor Subtypes in AtT-20 Cells
Abstract:Nonpeptidyl agonists for the somatostatin (SRIF) receptor family have been developed. We have studied the desensitization effects for two of these agonists upon SRIF receptor function in AtT-20 cells, a neuroendocrine tumor cell, which endogenously expresses two distinct SRIF receptor, subtypes. We observe that SRIF and the nonpeptidyl, subtype selective agonists, differentially regulate SRIF receptor subtypes in the AtT-20 cell.
Document Type: Review Article
Affiliations: Department of Biology, Seton Hall University, South Orange, NJ 07079
Publication date: April 1, 2004
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