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Factors Determining The Efficacy Of Alphahelical Antimicrobial Peptides

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Abstract:

A database of α-helical antimicrobial peptides (AMP) was established and their minimum inhibitory concentrations (MIC) were compared with their physiochemical characteristics in an attempt to establish those features that determine efficacy. There is no significant difference in AMP sensitivity between Gram-positive and Gram-negative bacteria but fungi did require higher concentrations to achieve the same degree of growth inhibition. For antibacterial peptides there appears to be a positive correlation between MIC and hydrophobic arc size and a negative correlation between MIC and net charge.

Keywords: Antimicrobial Peptides; Gram-negative bacteria; fungi; hydrophobic arc

Document Type: Review Article

DOI: https://doi.org/10.2174/0929866033478663

Affiliations: Department of Forensic and Investigative Science, and Dean, Faculty of Science, University of Central Lancashire, Preston, PR1 2HE, (UK).

Publication date: 2003-10-01

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  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.
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