Antimicrobial Peptides from Anurans Skin Secretions

Authors: Nascimento A.C.C.; Fontes W.; Sebben A.; Castro M.S.

Source: Protein and Peptide Letters, Volume 10, Number 3, June 2003 , pp. 227-238(12)

Publisher: Bentham Science Publishers

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Abstract:

This article is an overview of antimicrobial peptides found in anurans skin secretions. These molecules constitute an initial barrier against microbial infections because of their activity against a large array of microorganisms. These peptides hold remarkable pharmaceutical and technological interest since they selectively kill microorganisms and are unlikely to induce resistance in pathogens. Also, outstanding synergism occurs when these peptides are combined with classic antibiotics and other antimicrobial peptides.

Keywords: amphibians; skin secretion; antimicrobial peptides; amphipathic -helix

Language: English

Document Type: Review article

DOI: http://dx.doi.org/10.2174/0929866033478933

Publication date: 2003-06-01

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Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.