Low Content of Protein S29 in Ribosomes of Human Lung Cancer Cell Line A549: Detected by Twodimensional Electrophoresis
This study revealed that the content of protein S29 in ribosomes of cancer cell line A549 was distinctly low (equivalent to about 30% of that of 2BS). The conclusion was acquired based on the ratios of spot volume of ribosomal protein S29 to that of several other ribosomal proteins (S29 / L37a, S29 / L38, S29 / S27 and S29 / S28) in the same gel plate. The possible biological roles of ribosomal protein S29 in malignant transformation and translation regulation are briefly discussed.
Keywords: 2-dimensional polyacrylamide gel electrophoresis; cbb-chromium modified thiosulfate-silver staining; human liver cancer cell line 7721; human lung cancer; human lung cancer cell line a549; human lung normal cell line 2bs; northern blot; ribosomal protein s29
Document Type: Review Article
Publication date: February 1, 2003
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