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A Convenient Method for the Synthesis of Cprotected Esters of Boc- / Z-α,α- Dialkylamino Acids by the Mixed Carboxylic - Carbonic Anhydride Method

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The synthesis of C-protected esters of Boc- / Z-α,α-dialkylamino acids is accomplished by using alkyl / aryl chloroformate in presence of DMAP as a catalyst. The reaction proceeds through mixed carboxylic-carbonic anhydride, which was monitored by IR. The reaction was clean and complete in about 2 hr. All the esters prepared have been obtained in good yield and are fully characterized.
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Keywords: Carbonic Anhydride; Cprotected Esters; Dialkylamino Acids; chloroformate

Document Type: Review Article

Publication date: 2002-08-01

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  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.
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