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Biophysical Evidence of Lipid and Carbohydrate Binding Activities of Shrimp High Density Lipoprotein / B Glucan Binding Protein

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Abstract:

Crustacean High Density Lipoprotein / β-Glucan Binding Protein (HDL / BGBP) has been studied due to its role in nutrition and immune response via activation of the defense cells (hemocytes) upon binding 1,3-D-β-glucan carbohydrates. In this study, HDL / BGBP was found to be composed mainly of beta sheets, as determined by circular dichroism. Lipoprotein aggregation resulted when HDL / BGBP interacted with phospolipid vesicles, laminaribiose (1,3-β-glucan disaccharide) or heparin. HDL / BGBP has similar dissociation constants for laminaribiose (Kd=22 mM) or heparin (Kd=46 mM) as determined by 90° light scattering.

Keywords: Glucan Binding Protein; High Density Lipoprotei; heparin; laminaribiose

Document Type: Review Article

DOI: https://doi.org/10.2174/0929866023408706

Publication date: 2002-08-01

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  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.
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